|Awarded On||November 19, 2015|
|Title||Carbamoyl Phosphate Synthase-1: A new metabolic liability in non-small cell lung cancers|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ralph J DeBerardinis|
|Cancer Sites||Lung and Bronchus|
Lung cancer is the most common cause of cancer-related deaths worldwide and has been highlighted as an area of priority by CPRIT and the Texas Department of State Health Services. Among the various subtypes of non-small cell lung cancer (NSCLC), tumors with mutations in both the oncogene KRAS and the tumor suppressor LKB1 are particularly aggressive. Because both KRAS and LKB1 regulate energy metabolism at the cellular level, we explored whether cells harboring mutations in these two genes have specific metabolic requirements that could be exploited to kill them selectively. We discovered that KRAS/LKB1 NSCLC cells use an unconventional form of metabolism in which the building blocks for DNA...