|Awarded On||November 19, 2015|
|Title||Chemoprevention of Colon Cancer by Anti-inflammatory Blockade Using Neem|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Michael J Wargovich|
Use of anti-inflammatory drugs appears to protect against the development of colon cancer, yet their long-term use of these agents as cancer preventives is plagued by unacceptable toxicity such as bleeding, ulceration, impaired renal function and heart attacks. Yet targeting chronic inflammation as a colorectal cancer prevention strategy remains very promising, if safer anti-inflammatory agents can be found. From nature, the neem tree, native to India and Africa is highly prized for its anti-inflammatory activity in use as a traditional medicine. Our laboratory has unique access to a highly purified supercritical extract of neem leaf and we have identified a promising lead compound, nimbolid...