|Awarded On||November 19, 2015|
|Title||Understanding Biological and Physical Factors Affecting Response to Proton Therapy to Improve its Clinical Effectiveness|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Dragan Mirkovic|
|Cancer Sites||Brain and Other Nervous System, Head and Neck, Lung and Bronchus|
Radiation therapy, often in combination with other modalities, is used in the treatment of nearly two-thirds of the 1.7 million cancers diagnosed annually in the US. Its clinical effectiveness has steadily been improving with the latest advance being proton therapy.In principle, because of their unique physical properties, protons have the potential to be much more effective than the currently prevalent modality of photons. The most advanced, and potentially the most effective form of proton therapy, is intensity-modulated proton therapy (IMPT). IMPT is delivered with thin scanning beams (“beamlets”) of protons.Despite proton therapy’s high promise, clinical evidence of its superiority has b...