|Awarded On||November 19, 2015|
|Title||A novel epigenetic reader as therapeutic target in MLL-translocated pediatric leukemias|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Michelle Barton|
Cancer is the leading cause of disease-related death among children and adolescents in the United States. Leukemias, cancers of the bone marrow and blood, are the most common childhood cancers, that account for ~30% of all cancers in children versus ~2% in adult. The most prevalent leukemia types in children are acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Despite remarkable improvement in the treatment outcomes over the past decades, a high-risk subgroup of ALL patients that bear translocations involving the MLL (mixed-lineage leukemia) gene are particularly associated with poor response to standard treatments and dismal prognosis. The MLL gene is located on chromoso...