|Awarded On||November 19, 2015|
|Title||DNA damage-induced small non-coding RNAs: mechanism and their role in cancer development|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Yi Liu|
|Cancer Sites||All Sites|
DNA damage generated spontaneously or induced by environmental agents, when is not appropriately repaired, is the basis for the initiation of most tumors due to the activation and deregulation of genes promoting cancer and/or the loss of function of tumor-suppressing genes. Therefore, proper DNA repair after DNA damage is crucial for the prevention of cancer development. DNA damage is known to trigger a conserved DNA damage response from fungi to man that can detect the damage, delay cell proliferation and repair the damage. Understanding how this process occurs and how it is regulated will provide mechanistic insights into future design of cancer prevention and therapeutic approaches. We r...