|Awarded On||November 19, 2015|
|Title||Nanoparticle Targeted STAT3 Immune Expression|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Amy B Heimberger|
|Cancer Sites||Brain and Other Nervous System|
For the last several years there has been a great deal of enthusiasm for immunotherapeutic treatment of malignancies. This has been in large part due to recent FDA approvals of antibodies that are capable of targeting immune checkpoints (i.e. the breaks of the immune system). The key inflection point has now been reached in the field of immunology with a wide variety of robust targets, unique and innovative strategies that include and go beyond the targeting of cell surface molecules, and rigorous preclinical testing in state-of-the-art model systems. This proposal brings together unique and unprecedented expertise in immunology, neurosurgery, and translational biology, to work together to i...