|Awarded On||November 19, 2015|
|Title||Effect of Chest Radiation Therapy on Cardiomyocyte Turnover|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Hesham Sadek|
|Cancer Sites||All Sites|
There are currently over 270,000 survivors of childhood and adolescent cancers in the United States. Chest radiotherapy is an effective treatment modality for numerous types of these cancers, including Hodgkin lymphoma and bone cancers among others. Unfortunately, radiotherapy has significant deleterious effects on the heart that are far more pronounced in patients receiving the therapy at younger age. One of the most serious, and poorly understood side effects is the delayed effect of radiotherapy on the heart muscle. Epidemiological studies indicate that the majority of patients undergoing chest radiotherapy during adolescence and young adulthood develop fibrosis in the cardiac muscle and...