|Awarded On||November 19, 2015|
|Title||Computational live cell histology|
|Award Mechanism||Individual Investigator Research Awards for Computational Biology|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Gaudenz Danuser|
We rapidly gain genomic information of cancers, but tumors from different patients and even from different cells of the same tumor can exhibit vast genetic differences. This applies especially to melanoma, a deadly form of skin cancer, where diagnosis and definition of a robust treatment strategy based on the genomic profile is impossible. At the level of cells, however, heterogeneous genomic profiles seem to invoke universal programs to invade, survive and colonize distant organs. This supports the hypothesis that diverse oncogenic backgrounds converge to a few key functions that confer metastatic efficiency. Quantitative live cell histology is designed to identify cellular behaviors that a...