|Awarded On||May 18, 2016|
|Title||Targeting Histone Acetylation Readers in MLL-translocated Leukemias|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Xiaobing Shi|
Leukemias are cancers of the bone marrow and blood, mostly while blood cells. In children, leukemias are the most common cancers that account for almost 1 out of 3 cancers. The most prevalent childhood leukemia types are acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Despite remarkable improvement in the treatment outcomes over the past decades, a high-risk subgroup of ALL patients that bear translocations involving the MLL (mixed-lineage leukemia) gene are particularly associated with poor response to standard treatments and dismal prognosis. Rearrangements of the MLL gene account for about 80% of infant ALL and up to 50% of infant AML. In leukemias, MLL is found to fu...