|Awarded On||May 18, 2016|
|Title||Optical opening of blood-brain barrier for brain tumor drug delivery by plasmonic nanobubbles|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Zhenpeng Qin|
|Cancer Sites||Brain and Other Nervous System|
Brain tumors are known to be lethal, with a median survival of 14.6 months for glioblastoma multiforme. A major and unique obstacle for brain tumor drug delivery is the presence of blood-brain barrier. The blood brain barrier is a sophisticated structure that gives an optimal environment for brain function but also severely limits the penetration of anti-cancer drugs. The goal of our project is to develop a novel approach to optically open the blood-brain barrier thus allowing the access of a wide range of therapeutic drugs to brain tumor cells. Specifically, we will design and synthesize plasmonic nanomaterials to target the tight junction proteins, a critical component of the blood-brain b...