|Awarded On||May 18, 2016|
|Title||Quantitative mapping of intracellular protein-protein interactomes in healthy and cancerous cells|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Agrilife Research|
|Principal Investigator/Program Director||Jean-Philippe Pellois|
|Cancer Sites||All Sites|
Cells can become cancerous when the function of certain proteins becomes dysregulated. These proteins carried out their molecular function by binding to other intracellular partners. To date, understand how this network of interactions change when proteins become dysregulated is a challenge because we currently lack the technologies that would permit to probe interactions networks directly inside cells. In this proposal, we will develop a radically novel technology that addresses this challenge. It consists of delivering proteins modified with affinity labels directly inside cells. Affinity labels can leave a chemical trace on the protein’s interaction partners and these partners can then an...