|Awarded On||May 18, 2016|
|Title||Exploring Geminivirus-encoded suppressor of histone methyltransferases as an anti-cancer drug|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Agrilife Research|
|Principal Investigator/Program Director||Xiuren Zhang|
|Cancer Sites||Leukemia, Prostate|
The primary goal of this research is to engineer our newly discovered small protein that specifically targets histone methyltransfereases (HMTases) to control tumorigenesis in human. In human, DNA is packaged around proteins called histones to form a structure called chromatin. Small chemical tags like "methyl-group” attached to the histones can alter the structure of chromatin to block transcription and lower the activity of a gene. The enzymes that add the methyl-group to histone are known as HMTases. SUV39H and EZH2 are such two HMTases that add repressive marks onto histone tails in chromatin, blocking transcription of numerous tumor suppressors such as P15 and P16. As such, SUVH1 a...