|Awarded On||May 18, 2016|
|Title||RNA processing stress: a new therapeutic entry point in triple-negative breast cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Thomas Westbrook|
More than 400,000 women will succumb to breast cancer this year, underlining the urgent need for new strategies to prevent and treat breast cancer. While new therapies and early detection have reduced the incidence of advanced disease, many patients are not helped by our current standard of care. It is clear that new medicines are necessary. However, a major obstacle to helping cancer patients is the current paradigm used to discover new therapies. Significant advances in targeted therapies have been made for patients with two subtypes of breast cancer (ER-positive and HER2-amplified). These so-called “targeted therapies” strike at the heart of tumors by focusing on the genetic abnormalitie...