|Awarded On||November 16, 2016|
|Title||Targeting the HNF4A and WNT/Beta-catenin pathways in childhood malignant yolk sac tumors.|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||James F Amatruda|
|Cancer Sites||Ovary, Testis|
The long-term goal of our work is to improve the treatment of children with malignant yolk sac tumor. Yolk sac tumor (YST) is a cancer of the germ cells, the cells that give rise to the ovary and testis. YST is the most common type of germ cell cancer in children. While most children with YST are thankfully cured, there are still about 10% who will die of their disease. It is also troubling that the chemotherapy agents we use for treating YST can cause a host of long-term adverse health effects. Our work is aimed at developing new types of treatments that would target the tumors more effectively and specifically, sparing the normal tissue of the body. Recently, we studied the DNA genome ...