|Awarded On||November 16, 2016|
|Title||Primary Cilia in Cell Cycle Control and Tumorigenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Qing Zhong|
Although several drugs have been developed to target breast cancers expressing estrogen receptor (ER), progesterone receptor (PR) or Her2/neu, but effective treatment for aggressive breast cancer is still lacking. Increasing evidence suggest that a broad spectrum of human cancers including breast, ovary, prostate, and pancreatic cancers have reduced primary ciliogenesis, suggesting that defect in ciliogenesis might associate with tumorigenesis. The primary cilium is an antenna-like structure that protrudes from the surface of virtually all cells in the mammalian body. Cilia transduce signals from extracellular stimuli to a cellular response that regulates proliferation, differentiation, tra...