|Awarded On||August 16, 2017|
|Title||Role of HDAC8 and higher order chromatin structure in melanoma metastasis and therapy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Kunal Rai|
Metastatic spread of cancer cells makes is the most deadly stage of cancer progression. Most tumors are clinically manageable if they are contained within the site of their origin. Therefore, there is a great value in understanding the biological processes that regulate a cancer cells ability to metastasize. Melanoma is a highly metastatic disease whose incidence is rising over the years and the five-year survival rates are dismal. Although immunotherapy agents are showing tremendous promise for management of melanoma in the clinic, they are efficacious in only a subset of patients and therefore other strategies are needed for better treatment of this disease. Epigenetic processes drive cell...