Grant ID RP170466
Awarded On November 16, 2016
Title Targeting the Inflammatory Cancer Stem Cell Microenvironment of Triple Negative Breast Cancer with Leukocyte-mimetic Nanovesicles
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The Methodist Hospital Research Institute
Principal Investigator/Program Director Ennio Tasciotti
Cancer Sites Breast
Contracted Amount $896,951
Lay Summary

Triple negative breast cancer (TNBC) tumors, which lack the expression of progesterone receptor, estrogen receptor, and human epidermal growth factor receptor 2, account for 10-20% of all breast cancer patients. Currently, no targeted therapy exists for TNBC, linking this disease with poor prognosis and an increased risk of relapse and metastatic progression. A sub-population of cancer cells with stem cell-like features is believed to be responsible for this resistance to therapy and metastatic progression. The growth and self-renewal features of these cells are fueled by inflammation and key signaling pathways. Our proposed technology aims to revolutionize TNBC treatment by developing ther...

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