|Awarded On||November 16, 2016|
|Title||Telomere Maintenance Mechanisms in Neuroblastoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Texas Tech University Health Sciences Center|
|Principal Investigator/Program Director||Charles Reynolds|
|Cancer Sites||Brain and Other Nervous System|
Neuroblastoma is childhood cancer that can spontaneously regress without therapy or relentlessly progress in spite of intensive chemotherapy. For continual cell growth cancer cells must maintain the ends of chromosomes (called telomeres) which erode if not maintained by telomere maintenance mechanisms (TMM). The most common TMM uses an enzyme in cells called telomerase which is capable of adding DNA to the ends of chromosomes. Some cancers use a non-telomerase mechanism known as alternate lengthening of telomeres (ALT). Low-risk wide-spread neuroblastomas (known as stage 4S) can spontaneously regress without therapy; some stage 4S neuroblastomas progress and kill the patient. In collabor...