|Awarded On||August 16, 2017|
|Title||Probing Novel Concepts of the NF-kappaB Transcriptional Program in Human Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ivan D'Orso|
|Cancer Sites||All Sites|
Normal cells produce master transcriptional regulators that control key biological processes. The genetic inactivation of these factors and the processes that control their activity promote cancer development. One of these transcriptional regulators is NF-kB, which modulates the synthesis of a vast array of genes that control inflammation and cell survival. Deregulated NF-kB activation (oncogenic addiction) leads to chronic inflammation and uncontrolled cell growth (both cancer drivers). Thus, selective inhibition of the NF-kB pathway to induce cell death has emerged as a rational therapeutic approach to combat cancer. To date, however, no clear unique mechanism exists to target cancer cells...