|Awarded On||August 16, 2017|
|Title||Targeting a Novel Nuclease PAAN in Triple-Negative Breast Cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Yingfei Wang|
MicroRNA is a small non-coding RNA ubiquitously expressed in mammals and controls important physiological and pathological processes. A vast majority of microRNAs are down-regulated in triple-negative breast cancer, leading to tumorigenesis. However, the molecular mechanisms underlying microRNA dysregulation in human triple-negative breast cancer are still elusive. Recently, we identified macrophage migration inhibitory factor as a novel nuclease and named it as PAAN according to its new function. PAAN is highly expressed in primary triple-negative breast tumors. High levels of PAAN in breast tumors are inversely correlated with global down-regulation of microRNAs, but positively correlated ...