|Awarded On||August 16, 2017|
|Title||Optimization of a Novel Class of Microtubule Stabilizers That Circumvent Multiple Drug Resistance Mechanisms Through Crystal-Structure Guided Total Synthesis|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at San Antonio|
|Principal Investigator/Program Director||Douglas Frantz|
|Cancer Sites||All Sites|
For more than 70 years, Nature has provided some of the most important medicines to combat cancer. A recent study in 2016 showed that of the 175 drugs approved to treat cancer since the 1940’s, 85, or 49%, were actually natural products or direct derivatives. Natural products are chemical compounds produced by organisms as part of their normal daily fight for survival. With respect to cancer, most of these life-saving medicines including paclitaxel, vinblastine, etoposide, camptothecin and topotecan have been derived from various plant sources. Thus, the discovery and development of plant-derived natural products to identify new cancer treatments remains an important avenue of basic research...