|Awarded On||August 16, 2017|
|Title||Mitochondrial DNA Instability Engages a Cancer-Related Interferon Program to Modify the Immune Microenvironment and NAD+ Metabolome and Enhance Melanoma Growth|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Andrew West|
Malignant melanoma is a cancer of specialized skin pigment cells called melanocytes. The incidence of malignant melanoma continues to rise more rapidly than all other malignancies except lung cancer. Although early-stage melanoma can be cured by surgical excision of malignant tissue, the five-year survival rate for patients with advanced melanoma is roughly 39 percent, indicating the aggressive and lethal nature of this disease. Recently, immunotherapies that promote anti-tumor immune responses have opened promising avenues for late stage treatment, and a better understanding of the factors that influence the tumor immune environment will support more effective therapies. Mitochondria are c...