|Awarded On||August 16, 2017|
|Title||Isolation and in Situ Profiling of Circulating Tumor Cell Subpopulations Using a Hyperuniform Structured Microchip|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Tech University|
|Principal Investigator/Program Director||Wei Li|
|Cancer Sites||All Sites|
The enumeration and bio-analyses of circulating tumor cells (CTCs) have shown clinical significance in indicating cancer progression and can potentially be used to evaluate the effectiveness of a cancer treatment. It is known that specific CTC subpopulations, rather than the whole, are responsible for cancer metastases. Emerging microfluidic technologies have demonstrated great promise for the complete capture of the whole population of CTCs with high yield and enhanced purity. However, most existing devices simply isolate all CTCs in a blood sample without resolving them into distinct subpopulations, preventing us from ac uiring true insights into the metastatic potential of a specific CTC ...