|Awarded On||February 21, 2018|
|Title||Determining the role of polyploidization in liver cancer development|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Hao Zhu|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
Most cells (50-80%) in the liver are polyploid, but the functional role of polyploidy is unknown. Polyploid cells and organisms contain more than the two sets of chromosomes that diploids normally have. Polyploidization in the liver normally occurs around the time of weaning, but ploidy is dynamic and can increase after liver surgery , fatty liver disease, and other injuries . Despite these associations, the extent to which ploidy influences liver function or cancer risk remains unknown. Some have hypothesized that a high number of chromosome sets within cells is a long-term risk for cancer, while others think that this could be protective against cancer. To interrogate the function ...