|Awarded On||February 21, 2018|
|Title||Fasting-induced inhibition of leukemia development|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Chengcheng Zhang|
Acute lymphoblastic leukemia (ALL), which includes B cell and T cell subtypes (B-ALL and T-ALL), is the most common form of cancer in children and also occurs in adults. Although treatment of pediatric ALL is highly effective, a sizeable number of patients are non-responders. The prognosis for adult ALL patients is significantly worse than for pediatric ALL patients. Additionally, some types of ALL have a much poorer prognosis than others. New therapeutic targets and approaches are needed to effectively treat ALL. Using mouse tumor models, we demonstrated that fasting alone robustly inhibits the development of both B-ALL and T-ALL, but not acute myeloid leukemia (AML). Mechanistically, we fo...