|Awarded On||February 21, 2018|
|Title||Understanding metabolic regulation of pediatric glioma through mouse modeling and patient tumor interrogation in vivo.|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Robert Bachoo|
|Cancer Sites||Brain and Other Nervous System|
Pediatric brain cancer is among the most challenging tumors to treat, with short survival times despite intense multi-modality treatment. Progress has been made in identifying the genetic changes in these aggressive tumors and making the link between the mutations and processes that lead to malignant growth in the brain. Some genetic changes are well known to be important for reprogramming normal cellular metabolism to enable the cancer cells to generate energy and the building blocks of new cells. Targeting these processes is a potential new way to attack the cancer cells. Recent observations in adult brain cancers from our laboratory have challenged the longstanding view that the tumors ar...