|Awarded On||August 24, 2018|
|Title||Mechanisms of Drug Resistance in Lung Cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Neal Alto|
|Cancer Sites||Lung and Bronchus|
The future of cancer research lies in a personalization of medicine, where each patient’s treatment regime is tailored to the unique genetic makeup of their tumor. However, tumor resistance to chemotherapy continues to be a major threat to personalized medicine as the underlying mechanisms of drug resistance are often unclear. In addition, the identification of biomarkers that predict drug resistance in patients remains a major future challenge. This proposal investigates a potentially new mechanism of cancer cell resistance to a promising new class of chemotherapeutics, collectively termed “Smac-mimetics”. These small molecules kill tumor cells by initiating an inflammatory type of c...