|Awarded On||August 24, 2018|
|Title||Nanoparticle-Mediated Hyperthermia to Improve Chemotherapeutic Efficacy in HIPEC|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The Methodist Hospital Research Institute|
|Principal Investigator/Program Director||Ashley Holder|
Peritoneal malignancies or cancers that spread to the peritoneum (lining of the abdomen) pose a treatment challenge. IV chemo often has minimal effect on these cancers, and surgical resection alone may miss microscopic tumors. Currently, recommended treatment is surgical removal of visible tumors followed by filling the abdomen with a heated chemo (HIPEC) bath to kill remaining cancer cells. This method has shown significant survival benefit for patients with metastatic gastric, colorectal, and ovarian cancers, with cures reported in patients with appendix cancer. Since the current HIPEC technique has a considerable recurrence risk and causes digestive dysfunction for up to a year after surg...