|Awarded On||August 24, 2018|
|Title||Methods for Assessment and Quantification of Imperfect dsDNA Break Repair|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Zbyszek Otwinowski|
|Cancer Sites||Breast, Ovary, Prostate|
Defective DNA repair may be inherited and so could be present in every cell of the body. Alternatively, it may appear at some point during tumorigenesis and thus be restricted to only a subset of cells. In both cases, such defects will result in elevated mutation levels. These mutations will follow patterns which are shaped by the specific DNA repair pathway that has been affected, the stage of tumorigenesis, and also by tissue-specific and environmental factors. There is an ongoing effort to identify and classify a category of these mutations known as clonal mutations, which are amplified in specific tissues, for instance by cancer growth. However, current sequencing methods are not sensiti...