Grant ID RP180813
Awarded On August 24, 2018
Title BRCA Answers From Cancer Interactome Structures (BACIS)
Program Academic Research
Award Mechanism Multi-Investigator Research Awards (Version 2)
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director John Tainer
Cancer Sites Breast
Contracted Amount $5,969,140*

*Pending contract negotiation

Lay Summary

Patients with BRCA type breast cancer are often successfully treated with cisplatin and PARP inhibitor (PARPi). Unfortunately, after initial success, relapse is common and associates with resistance to further therapy. Thus, development of resistance is a fundamental problem facing BRCA patients. This BACIS Program aims to provide solutions from a molecular level understanding of the processes controlling the sensitivity and the resulting resistance. Efforts will focus on BRCA mechanisms underlying PARPi sensitivity and those with a significant probability of causing therapeutic resistance. Besides understanding the underlying mechanisms of resistance, we expect to find missing biological vu...

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