|Awarded On||August 24, 2018|
|Title||BRCA Answers From Cancer Interactome Structures (BACIS)|
|Award Mechanism||Multi-Investigator Research Awards (Version 2)|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||John Tainer|
Patients with BRCA type breast cancer are often successfully treated with cisplatin and PARP inhibitor (PARPi). Unfortunately, after initial success, relapse is common and associates with resistance to further therapy. Thus, development of resistance is a fundamental problem facing BRCA patients. This BACIS Program aims to provide solutions from a molecular level understanding of the processes controlling the sensitivity and the resulting resistance. Efforts will focus on BRCA mechanisms underlying PARPi sensitivity and those with a significant probability of causing therapeutic resistance. Besides understanding the underlying mechanisms of resistance, we expect to find missing biological vu...