|Awarded On||August 24, 2018|
|Title||Pediatric Solid Tumors Comprehensive Data Resource Core|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Richard Gorlick|
|Cancer Sites||Bone, Brain and Other Nervous System|
*Pending contract negotiation
Despite improvements in survival rates for childhood cancers, high-dose radiation and chemotherapy used as standard of care cause significant quality of life problems in survivors. Tumors also frequently recur or metastasize, and these are refractory to current therapies. These children are at added risk for secondary malignancies in the long-term, and there are no therapeutic options. Thus, there is a need to develop precision therapies that take advantage of differences in biology between normal and tumor tissues. In adult cancers, studying mutations and other genomic alterations during the course of treatment has provided researchers and clinicians with information on tumor evolution, whi...