|Awarded On||August 24, 2018|
|Title||Molecular Opening of the Blood-Brain Barrier by Molecular Hyperthermia|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Zhenpeng Qin|
|Cancer Sites||Brain and Other Nervous System|
Glioblastoma, the most common primary adult brain tumor, is among the most lethal of all solid tumors with a median survival of 14.6 months, which has remained unchanged for over a decade despite intense therapeutic efforts. A unique and major unmet challenge of treating brain tumor is difficulty of delivering effective drugs across the blood-brain barrier (BBB). Our long-term goal is develop an effective strategy to transiently increase BBB permeability that will permit effective delivery of antineoplastic drugs. The specific goal of this project is to design and synthesize light absorbing nanoparticles that target endothelial cell tight junction associated proteins, which form a critica...