|Awarded On||February 21, 2019|
|Title||Mitochondrial Metabolism and RNA Methylation in Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Ricardo Aguiar|
|Cancer Sites||Leukemia, Lymphoma|
*Pending contract negotiation
Epigenetic deregulations are those that lead to change in gene levels without altering the genetic code. Epigenetic remodeling is an integral part of cancer initiation, maintenance and progression. DNA methylation is the most studied epigenetic change. However, recent evidence suggests that RNA methylation is as important as DNA methylation to human physiology and pathology, including cancer. RNA methylation is tightly controlled by the abundance and activity of proteins that promote it (RNA methyltransferase) and those that terminate it (RNA demethylases). We discovered that a ubiquitous cancer promoting gene, MYC, is a critical regulator of RNA methylation. Our data suggest that MYC induce...