|Awarded On||February 21, 2019|
|Title||Improving T-Cell Therapy of Neuroblastoma With a Novel Cytokine Modulator: A Phase 1 Clinical Trial|
|Award Mechanism||Individual Investigator Research Awards for Clinical Translation|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Cliona M Rooney|
|Cancer Sites||Brain and Other Nervous System|
*Pending contract negotiation
Neuroblastoma is a cancer in children that is very difficult to treat if it spreads through the body. A new way of fighting this disease is to use some of the body’s own immune cells to kill the cancer cells. For this treatment a few teaspoons of blood are taken from the child with neuroblastoma and the cells are genetically reprogrammed to recognize and kill neuroblastoma cancer cells. These reprogrammed cells, called “chimeric antigen receptor” cells or CAR cells, have already cured several children with neuroblastoma at our hospital. However, in other children, this treatment has only partially worked and in some cases the cancer has come back. We believe that the effect of CAR cells i...