Grant ID RP190067
Awarded On February 21, 2019
Title Improving T-Cell Therapy of Neuroblastoma With a Novel Cytokine Modulator: A Phase 1 Clinical Trial
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Cliona M Rooney
Cancer Sites Brain and Other Nervous System
Contracted Amount $1,499,252*

*Pending contract negotiation

Lay Summary

Neuroblastoma is a cancer in children that is very difficult to treat if it spreads through the body. A new way of fighting this disease is to use some of the body’s own immune cells to kill the cancer cells. For this treatment a few teaspoons of blood are taken from the child with neuroblastoma and the cells are genetically reprogrammed to recognize and kill neuroblastoma cancer cells. These reprogrammed cells, called “chimeric antigen receptor” cells or CAR cells, have already cured several children with neuroblastoma at our hospital. However, in other children, this treatment has only partially worked and in some cases the cancer has come back. We believe that the effect of CAR cells i...

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