Grant ID RP190131
Awarded On February 21, 2019
Title Neoadjuvant Treatment Response Monitoring of Breast Cancer With Molecular Photoacoustic Imaging
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Richard Bouchard
Cancer Sites Breast
Contracted Amount $895,907*

*Pending contract negotiation

Lay Summary

Close to 40,000 Americans will be diagnosed with triple-negative breast cancer (TNBC) in 2018, a subtype of invasive breast cancer with a poor prognosis. Patients with TNBC are preferably treated with neoadjuvant chemotherapy (NAC), which results in ~50% of patients having either pathologic compete response (pCR) or minimal residual disease upon resection. However, not all patients have a substantial response to NAC, and thus there is a dire clinical need for a non-invasive modality that is capable of monitoring therapy response to allow for timely modifications to one’s treatment plan or to assess the degree/location of residual disease. Recently, photoacoustic-ultrasonic (PA-US) imaging ha...

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