|Awarded On||February 21, 2019|
|Title||Role of S1PR1 in Exercise-Induced Tumor Vascular Remodeling|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Keri Schadler|
|Cancer Sites||Bone, Sarcoma|
Ewing sarcoma occurs in the bone and soft tissue, most often in adolescents. Chemotherapy drugs are part of the standard care for cancer patients, and increasing delivery of chemotherapy specifically to the tumor is likely to make the chemotherapy work better. Chemotherapy is delivered to the tumor by the blood vessels, but tumor blood vessels do a poor job of delivering chemotherapy throughout the tumor. Reorganizing blood vessels to make them deliver chemotherapy more effectively has been demonstrated to increase patient survival in patients with glioblastoma, breast cancer, and even Ewing sarcoma, but there is not yet a good way to make the blood vessels work better without causing more t...