Grant ID RP190259
Awarded On August 21, 2019
Title Role of the N6-methyladenosine (m6A) writer METTL3/METTL14 in cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Yunsun Nam
Cancer Sites Gallbladder, Leukemia, Liver and Intrahepatic Bile Duct, Uterus
Contracted Amount $900,000*

*Pending contract negotiation

Lay Summary

When genetic information is transferred from DNA to RNA and then protein, messenger RNA can be controlled in various ways. Not only does RNA need to be properly spliced, but it also requires help for initiating translation. Moreover, RNA stability is important as it determines how much protein can be translated from the RNA. A chemical modification, specifically methylation, of RNA has been shown to regulate all of these critical steps of the RNA life cycle. RNA methylation is reversible, and all of the enzymes involved--writers, readers, and erasers--have been implicated in having some role in cancer. However, because we know little about how the modification is added to the RNAs, it has be...

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