|Awarded On||February 21, 2019|
|Title||Investigating Brain Tumor Drug Delivery by Optical Modulation of Blood-Brain Barrier Using Plasmonic Nanobubbles|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Zhenpeng Qin|
|Cancer Sites||Brain and Other Nervous System|
*Pending contract negotiation
Brain tumors are known to be lethal, with a median survival of 14.6 months for glioblastoma multiforme. A major and unique obstacle for brain tumor drug delivery is the presence of blood-brain barrier (BBB). The BBB is a complex protein structure associated with cerebral capillaries, which prevent entry of even the smallest molecules into the brain parenchyma, thereby severely limiting evaluation of potentially efficacious anti glioma therapies. The goal of our project is to develop a novel approach to optically open the BBB thus allowing the access of a wide range of therapeutic drugs to brain tumor cells. We propose to temporarily open the BBB by targeting nanoparticles to the cell-to-ce...