Grant ID RP190279
Awarded On February 21, 2019
Title Mechanisms of Prevention of Polycyclic Aromatic Hydrocarbon (PAH)–Mediated Lung Carcinogenesis by Omega-3 Fatty Acids
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Bhagavatula Moorthy
Cancer Sites Lung and Bronchus
Contracted Amount $899,151*

*Pending contract negotiation

Lay Summary

Environmental carcinogens such as polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke can bind to DNA to form DNA adducts (additional products), which may lead to mutations in critical genes, eventually leading to cancer. A positive correlation between PAH-DNA adducts and tumor incidence was observed by us (Arch Toxicol, 2015). Epidemiological data show that people with higher levels of PAH-DNA adducts are 2-3 times more to have lung cancer in the future than those with lower adduct levels. Therefore, reduction of DNA adduct levels may decrease risk of lung cancer. We discovered that dietary fish oil that contains omega-3 fatty acids decreased lung and liver DNA addu...

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