Grant ID RP190287
Awarded On August 21, 2019
Title Regulation of CD8 T cell responses in antitumor immunity
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Shao-Cong Sun
Cancer Sites All Sites
Contracted Amount $900,000*

*Pending contract negotiation

Lay Summary

Immunotherapy has become a highly promising approach for cancer treatment. The immune system is evolved as a mechanism that detects and attacks foreign substances, such as microbial pathogens. On the other hand, the immune system does not attack cells or tissues of our body, which is the so-called immune tolerance. Cancer cells accumulate genetic mutations, making them different from normal cells. However, because the differences between cancer cells and normal cells are small, the immune system is usually tolerant to the cancer cells and does not mount strong responses to attack them. The general principle of tumor immunotherapy is to stimulate the tumor-specific T-cell responses strongly e...

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