Grant ID RP190358
Awarded On August 21, 2019
Title The Role of ZMYND8 in Breast Cancer Stem Cells and Tumor Progression
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Weibo Luo
Cancer Sites Breast
Contracted Amount $900,000*

*Pending contract negotiation

Lay Summary

Breast cancer metastasis is responsible for more than 90% of cancer death in women and is thought to be caused by breast cancer stem cells that are often located in regions without sufficient oxygen supply (a phenomenon known as hypoxia). Hypoxia-inducible factor (HIF) is a master regulator frequently detected in the hypoxic regions and controls cellular responses to hypoxia. Previous studies have shown that HIF is critical for breast cancer stem cells to survive and spread around the body. However, the precise mechanism by which hypoxia/HIF regulate breast cancer stem cells to promote breast cancer metastasis remains unknown. We recently discovered ZMYND8, a protein that is highly expressed...

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