Grant ID RP190400
Awarded On February 21, 2019
Title Utilization of Imaging and Serum Biomarkers to Predict the Development of Cardiac Dysfunction in Childhood Cancer Survivors
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Cory V Noel
Cancer Sites Leukemia, Lymphoma, Sarcoma
Contracted Amount $1,192,412*

*Pending contract negotiation

Lay Summary

Survival rates of childhood cancer have improved, but there is a growing population of childhood cancer survivors with significant heart disease. Anthracycline has a particularly high risk. Unfortunately, anthracycline is partly responsible for improved cancer survival, and thus remains a treatment in over 50% of childhood cancer patients. Oncologists are aware of this risk, and try to identify when the heart is affected. The usual method is by echocardiography. However, echocardiography has limitations that make it ill-equipped to consistently identify patients. One limitation is the detection of a problem is often too late to allow changes. Cardiac MRI is the best test when evaluating hear...

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