|Awarded On||August 21, 2019|
|Title||A Mouse Model for Studying DIPG Initiation and Progression in the Pons|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Zhigang Xie|
|Cancer Sites||Brain and Other Nervous System|
*Pending contract negotiation
Brain cancer is the leading cause of cancer-related death in children. This project studies diffuse intrinsic pontine gliomas (DIPGs), the deadliest form of pediatric brain cancer. A major obstacle in the field of DIPG research is the lack of animal models in which endogenous tumors are induced by representative DIPG genetic mutations in typical DIPG locations. This type of animal models is available for studying most other cancers, including adult brain cancer, and is among the most useful tools for understanding the mechanisms of cancer initiation and progression. However, existing animal models of DIPGs either do not induce endogenous tumors, or do not use representative DIPG genetic muta...