|Awarded On||February 21, 2019|
|Title||Modulating Cardiomyocyte DNA Damage in Response to Genotoxic Stress|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Hesham Sadek|
|Cancer Sites||All Sites|
Chest radiotherapy and systemic chemotherapy are the effective treatment modalities for numerous types of cancers, including Hodgkin lymphoma and bone cancers among others. Unfortunately, cancer therapeutics have significant deleterious effects on the heart that are far more pronounced in patients receiving the therapy at younger age. One of the most serious, and poorly understood side effects is the delayed effect of cancer therapeutics on the heart muscle. Epidemiological studies indicate that the majority of patients undergoing chest radiotherapy during adolescence and young adulthood develop fibrosis in the cardiac muscle and are six times more likely to develop heart failure. Similarly,...