Grant ID RP190570
Awarded On August 21, 2019
Title Expression landscape and biomedical significance of transfer RNAs in cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Leng Han
Cancer Sites All Sites
Contracted Amount $199,998*

*Pending contract negotiation

Lay Summary

Transfer RNA (tRNA) is an adaptor molecule composed of RNA, that is typically 76 to 90 nucleotides in length and serves as the physical link between the mRNA and the amino acid sequence of proteins. Recent studies showed that tRNAs have significant roles in cancer. We took advantage of the large number of patient samples (>10,000) in The Cancer Genome Atlas (TCGA) across >30 different cancer types to study the biomedical significance of tRNAs in cancer. By analyzing the expression levels of tRNAs at the gene, codon and amino acid levels, we revealed unequal alterations in tRNA expression, which is largely due to the uneven distribution of tRNAs decoded for different codons and amino ac...

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