|Awarded On||August 21, 2019|
|Title||Expression landscape and biomedical significance of transfer RNAs in cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Health Science Center at Houston|
|Principal Investigator/Program Director||Leng Han|
|Cancer Sites||All Sites|
*Pending contract negotiation
Transfer RNA (tRNA) is an adaptor molecule composed of RNA, that is typically 76 to 90 nucleotides in length and serves as the physical link between the mRNA and the amino acid sequence of proteins. Recent studies showed that tRNAs have significant roles in cancer. We took advantage of the large number of patient samples (>10,000) in The Cancer Genome Atlas (TCGA) across >30 different cancer types to study the biomedical significance of tRNAs in cancer. By analyzing the expression levels of tRNAs at the gene, codon and amino acid levels, we revealed unequal alterations in tRNA expression, which is largely due to the uneven distribution of tRNAs decoded for different codons and amino ac...