|Awarded On||August 19, 2020|
|Title||Establishment of a Prospective Cohort at Risk for HPV-Related Cancers: Using HPV Testing at Mucosal Sites and Blood-Based Assays for Risk Stratification in Men|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Erich Sturgis|
|Cancer Sites||Colorectal, Head and Neck, Penis|
This proposed study will build upon ongoing bi-institutionally funded prospective cohort studies of adults at high-risk for human papillomavirus (HPV)-related cancers, especially HPV-related oropharyngeal cancer (OPC). HPV-related OPC is the most common HPV-related cancer, is projected to rise in incidence over the next several decades despite ongoing vaccination efforts, is predominantly caused by the HPV16 strain, and primarily affects men compared to women (~6:1 ratio) at middle- and elderly ages. Oral HPV16, HPV16 early (E) antigen antibodies and circulating HPV16 DNA (cHPVDNA) are valid biological markers of HPV-related disease. This proposal will fund the development of the largest kno...