|Awarded On||February 19, 2020|
|Title||PPAR-Alpha Modulation of DNA Sensing and Interferon Induction|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Tiffany A Reese|
|Cancer Sites||Lymphoma, Sarcoma|
*Pending contract negotiation
Infectious agents cause approximately 20 percent of cancers. Oncogenic herpesvirus are a leading cause of lymphomas and tumors induced by viral infection. All of us are infected with at least one herpesvirus, but only a small fraction of people will develop a herpesvirus-induced cancer. Our lab investigates regulation of herpesvirus infection by the immune system to determine ways to prevent and treat herpesvirus-induced cancers. In the context of herpesvirus infection, we are investigating the mechanism of immune system recognition of viral and host DNA. We are studying a particular pathway involved in sensing foreign DNA or damaged host DNA in the cytoplasm of cells. This DNA sensin...