|Awarded On||August 19, 2020|
|Title||Targeting the CXCL10-CXCR3 Axis in Metastatic Osteosarcoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Tsz-Kwong Man|
Osteosarcoma is the most common bone cancer in children and young adults. While this bone cancer is rare in adults, it ranks only behind lymphomas and brain tumors as the most prevalent childhood solid tumor. With the introduction of surgery and chemotherapy, the survival of osteosarcoma patients has dramatically improved since the 1980s. Nonetheless, advances in improving the prognosis of the patients with this childhood cancer have not improved over the past three decades. In particular, the survival for patients with metastatic disease is still poor with a five-year survival rate below 20% under the current standard of care. Since a metastasis-specific regimen is not available, all patien...