|Awarded On||August 19, 2020|
|Title||Targeted Inhibition of Autophagy for Treatment of Dormant Ovarian Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Steven Millward|
Ovarian cancer carries an extremely poor prognosis when diagnosed at Stage 3 and 4. In most cases, surgical resection followed by chemotherapy leads to an initially promising outcome, which is later reversed when resistant disease emerges. The work of co-investigators Robert C. Bast and Zhen Lu has shown that autophagy is turned on in small, residual ovarian cancer nodules that remain after surgery and chemotherapy. Autophagy is a process in which cellular components (e.g. organelles) are engulfed by vesicles called autophagosomes where they are degraded to provide metabolic fuel to keep tumor cells alive. Although autophagy is known to play a significant role in tumor dormancy and resistanc...