|Awarded On||August 19, 2020|
|Title||Role of HOTTIP lncRNA in Leukemogenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Mingjiang Xu|
Long non-coding RNAs (lncRNAs) influence many critical cellular processes such as gene expression. The initiation and progression of myeloid leukemia have thus far been studied mainly within the realm of mutations and/or dysregulation of key protein-coding genes. Whether lncRNAs affect the initiation and progression of malignant myelopoiesis remains to be determined. In addition, elucidating the mechanistic roles of oncogenic lncRNAs will provide the intellectual and experimental framework for developing targeted therapeutics for myeloid leukemia. We have initiated efforts to identify pivotal oncogenic lncRNAs in the pathogenesis of myeloid leukemia. This endeavor has yielded highly promisin...